Synthesis of iron oxide core chitosan nanoparticles in a 3D printed microfluidic device

Nanostructures are capable of major changes in our life. However, the game changing properties experimental nanostructures mostly not repeatable for industry and it is easy to produce amount nanoparticles necessary industrial world. Repeatable methods, which do require highly trained personnel, industrial-scale production should be developed transfer academic research use people. Although there various successful microfluidics devices that have been designed microstructures synthesis, synthesis an enlightened area a need reach better state. Especially, development design biopolymeric very important. The uses both nanotechnology nanomedicine especially as theragnostic tools. In this study, microfluidic device has modeled, designed, manufactured iron oxide core chitosan nanoparticles. channels were by 3D printing. After synthesized device, these particles characterized, their examined. addition flow rate, chemical concentrations, pH, structure channel hurdles effects on particle size distribution. Best results obtained with 120-120ml/h rates 0.06-0.03% concentrations at pH 4.5 chitosan-tripolyphosphate couple. produced microchannels under conditions DLS measurement 190±15 nm diameter 69% intensity. conclusion, printed able synthesize reproducible way or without core.